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Dimethylglycine - Dimethylglycine (DMG) - Facts

Dimethylglycine (DMG) - Facts

Dimethylglycine (DMG) is technically classified as a food. It is found, in trace amounts in some foods, such as brown rice and liver. Chemically it resembles the water-soluble vitamins, such as the B vitamins. The main reason it is not classified as a vitamin is that there are no specific symptoms associated with a deficiency of DMG.
Many parents have reported that, within a few days of starting DMG, the child's behavior improved noticeably, better eye contact was seen, frustration tolerance increased, the child's speech improved, or more interest and ability in speaking was observed. See Rimland, "Dimethylglycine (DMG) in the Treatment of Autism."
Background Data

There is extensive literature on the safety and health benefits of DMG. Many studies have shown that DMG enhances the effectiveness of the immune system, improves the physical and athletic performance of humans and other animals (e.g. race horses) and has all in all a wide range of beneficial effects. It is very safe; no evidence has been seen of any toxic or significant adverse effects, with even taking massive intakes of DMG.

In 1965, two Russian investigators, M.G. Blumena and T.L. Belyakova, published a report showing considerable improvement in the speech of 12 of a group of 15 mentally handicapped children who had not been able to use speech to communicate. The children had been treated with a substance variously known as calcium pangamate, or pangamic acid, or "Vitamin B15" in addition to enriched vocabulary the children began to use simple sentences, their general mental state improved, and there was better concentration and interest in toys and games. Subsequent research has shown the essential factor in calcium pangamate to be DMG.

DMG is a metabolic enhancer, that is, it improves the function of several metabolic pathways, including those involving the immune system, the cardiovascular system, and muscle performance. Although excess DMG is converted by the body into energy, it appears that it's primary role in metabolism is to act as a key intermediary in the biological pathway that supplies the body with methyl groups. It maximizes the amount of energy produced for each molecule of oxygen consumed, and stimulates both branches of the immune system. DMG is an ergogenic nutrient that is, it helps produce energy and improve physical stamina.

DMG also acts as a detoxifying agent and antioxidant, protecting body cells from unwanted reactions caused by free radicals. Extensive animal and clinical tests have shown DMG to be a versatile normalizer of physiological functions.

The chemical structure of DMG is that of the amino acid glycine, in which two of the hydrogen atoms have been replaced by methyl groups.

Dr. Jerzy Meduski of the Nutritional Research Laboratory, at the University of Southern California's School of Medicine in Los Angeles, has studied the safety of DMG for more than five years. He concludes that DMG is perfectly safe when used as a dietary supplement. DMG is actually as safe as Vitamin C. In an animal study, Dr. Meduski found that consuming 1.85 grams of DMG per kilogram of body weight (equivalent to 130 grams for a 154 pound person) had no effect on blood pressure, breathing patterns, blood chemistry, oxygen intake, or body weight. At the same time, DMG was found to produce a measured increase in athletic performance and a decrease in lactic acid, the compound that forms in muscles and causes tiredness.

Many parents have reported that within a few days of starting DMG with their autistic child, the child's behavior improved noticeably, better eye contact was seen, frustration tolerance increased, the child's speech improved, or more interest in speaking was observed. An article in the New England Journal of Medicine (October 1982) reported that a 22 year-old mentally retarded man who had 16 to 18 seizures per week on standard anticonvulsants, experienced only three seizures per week while on DMG. Two attempts to remove the DMG dramatically increased seizure frequency.

If you are just starting out we suggest giving the DMG for 2-3 weeks and only then to start taking B6 and Magnesium. So that one shouldn't confuse the results by simultaneously starting other vitamins, drugs, or other forms of treatment that might make it difficult to tease out the effect of DMG from the effects of other things tried. However, if the child is already taking Vitamin B6 and Magnesium or anything else that is helpful, there is no reason to stop taking them. The DMG is merely a high concentrated food. It may in fact improve the effectiveness of the B6.
Scientists find that Dimethylglycine increases immune function 300%
Mark Konlee
Scientists find that Dimethylglycine increases immune function 300%
In 1981, when AIDS was first called GRID (Gay Related Immune Disorder), and the HIV virus had not yet been discovered, important research on the immune modulating effects of dimethylglycine was published in the Journal of Infectious Diseases (1).
Graber CD et al state that dimethylglycine presumably "enhances oxygen utilization by tissue and complexes free radicals." In a double-blind study on 20 humans, they found a fourfold increase in antibody response to vaccines as compared to controls. In studying cell-mediated immune responses to phytohemagglutinin, convanavalin A and pokeweed mitogen, they found an almost threefold increase in responses. They concluded that DMG enhanced both arms of the immune system.
Last month, I reported on DMG and 5 readers are now trying the Food Science brand using 750 mg daily sublingually. (2 tablets 3 times daily are dissolved under the tongue). Results on increasing CD4 counts and its effects on viral load should be known in a few months).
Sublingual DMG is probably a more effective methyl donor that oral TMG or oral DMG. Increased oxygen utilization inside the cells can inactivate intracellular viruses, fungus and bacteria. Folic acid supports an enzyme that breaks down DMG and the breakdown products are likely where the benefits reside. Liquid B12 and Folic acid by Bricker Labs also taken under the tongue would be a good choice to use along with DMG. Folic acid supports the methylation process.
1. Immunomodulating properties of dimethylglycine in humans, Graber CD et al; J. Infect Dis 1981 Jan;143(1):101-5.

The following is a reprint from the 4th edition of the AIDS Control Diet book by Mark Konlee from July, 1992. The AIDS Control Diet book is the forerunner of the current book on How To Reverse Immune Dysfunction:
"Early in July (1992), we talked to a man from California who had contacted us...He told us that 3 months earlier, he had doubled his T4 counts for 120 to 240 in one month by taking 800 mg daily of DMG - or Di-Methyl Glycine. He had been on AZT for one year previous to this with his T4 counts holding steady at about 120. He attributes the increase to the DMG. Then, he reportedly told four of his friends about his experiences with the DMG. They also tried it and used about 800 mg per day (sublingually). Everyone reported a significant increase in T4 counts. One man reportedly went from 45 to 170 in 2 months. Here in Milwaukee, one man took 200 mg of DMG (not 800) daily for 6 weeks and told us his T4 count increased from 14 to 34. One person who has severe KS and intestinal absorption problems took an oral form of DMG from Enzymatic therapy. After 2 months, there was no change in his T4 counts."
The above report somehow got deleted from future editions of the AIDS Control Diet book and subsequently the book on How To Reverse Immune Dysfunction. In light of the recent discoveries of the benefits of methylation in stopping replication of HIV and other viruses inside the cells, we need to retest the effects of DMG as an immune modulator or antiviral agent. DMG, like TMG, folic acid, L methionine and even alcohol support methylation.

In this time period, 1992, AIDS treatments came and went weekly. This one, however, may have been sent down the pike erroneously. As I recall the conversation, the DMG was absorbed sublingually - under the tongue and not simply swallowed with water. Two factors are critical to reproducing these results. One is to use the correct dosage. Too low a dose might produce no results at all or inconsistent results and the second is how the DMG is taken. The CD4 increases from DMG absorbed sublingually in the mouth where it directly entered the blood stream. It did not occur from swallowing oral capsules. Sublingual absorption widely used in homeopathy acts like an injection where oral swallowing of a product can sometimes lead to degradation in the stomach and small intestines from digestive acids and enzymes.

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